Data Mining and Machine Learning
Automatic enumeration of a combinatorial Library for virtual screening.
About Me
I am a chemist by training working for Chemical Computing Group in Cologne as a Principal Scientist. My professional focus is software supported drug design.
I am not doing the actual drug design but am involved in applying computer methods to predict biologic activity of compounds and development of new methods in that field.
Between 2012 and 2016 I was a board member of the CIC section of the German Chemical Society.
In my private life I am a wildlife photographer. But even as I see myself as a underwater photographer, that does not exclude visiting Zoos, Natural Reserves and nearby
forests always looking for good motives.
Another of my hobby is tropical fish keeping. I have been breeding Central American cichlids for many years and I am a member of the German Cichlid Association.
Molecular Design
There are trillions of possible chemical structures. This vast number makes it impossible to screen them all in order to find an active lead molecule. Molecular Modelling is a collection of methods allowing to predict biological activity of a virtual compound before it is even synthesized. This reduces the number of required animal tests and allows focused synthesis of highly promising compounds.
Quantum mechanics
Electrostatic potential mapped on the molecule surface of Molnupiravir (SARS-Cov2)
Sequence Alignment
Superposition of several spike protein (SARS-Cov2) variants color coded by sequence similarity
Enzym Inhibition
3D QSAR
Quantitave Structure Activity Relationship based on a 3D alignment of various PDK 1 inhibitors (Breast cancers)
Pharmacophore
Extraction of a non bonded interasction pattern based on retroviral transcriptases (HIV)
Underwater Photography
Soon after becoming a certified Open Water Diver, I started taking photos of the under water wonderland. My first camera was a compact but with increasing ambitions I had to switch to a DSLR with housing and strobes. The focusing speed under low light conditions makes DSLR superior over any other system. I also upgraded my dive gear to a Razor2 sidemount configuration giving me the redundancy and buoyancy control required for photo dives.
Dive Site: Utopia Beach House Reef, El Quesir, Egypt
Portrait - Hedgehog Fish
Dive Site: Utopia Beach House Reef, El Quesir, Egypt
Macro - Fresh water jelly fish
Dive Site: Gut Widdauen, Germany
Behaviour - Moray Eel with Cleaning Shrimp
Dive Site: Utopia Beach Hausriff, El Quesir, Ägypten
Fresh Water - European Pike
Dive Site: Angermund, Germany
Fisheye - Dolfin
Dive Site: Utopia Beach House Reef, El Quesir, Egypt
Wildlife Photography
While you can be certain to find some nice motives in a zoo, taking pictures in the wild is far more challenging. You will need a lot of patience, luck and good equiment. Beside some larger species we have a lot of interesting small species in our area, that make excellent motives for macro.
Stork
NSG Bislicher Insel
Kingfisher
NSG Saarner Aue
Squirrel
NSG Saarner Aue
Yellow bellied toad
Southern eifel
Natterjack toad
Mosel valley
Wall lizard
Mosel valley
Zoo Photography
I often spend weekends in zoos. I not only try to study animal behavior there but also try to take pictures of the best moments.
Borneo Orang-Utang
Zoo Dresden
Racoon
Zoom Erlebniswelt
White Tiger
Pairi Daiza
Polar fox
Dierenrijk
Dwarf otter
Burgers Zoo
Capuchin monkey
Apenheul
Lion
Zoo Dresden
Fire Skink
Cologne Zoo
Bat-Eared Fox
Bergzoo Halle
Aquarium Photography
I started keeping tropical fish in the age of 12. When I first got aCanon T70 camera I began experimenting with photography. I really got stared when I got a T90 with flash TTL. Then it took me quite some time to make the transition to a DSLR because I found the quality of digital ../images not convincing. That changed only a few years ago. Today I'm working with a Conon R5, EX580 flash and several Macro lenses.
Portrait - Vieja melanurus
My Aquarium
Behaviour - Spawning Rainbow Cichlids
My Aquarium
Full Shot - Cichla monoculus
Zoo Antwerpen
Meerwasser - Pomacanthus annularis
Aquarium, Zoo Cologne
Landscape - Amazon
Aquarium Leipzig Zoo
Public Aquarium - Blacktip Reef Shark
Ruhrzoo Bochum
Blog
In my blog I will show selcted photos from my trips and zoos I visited. I will also
publish longer texts about topics that are of interest for me on a regular basis.